Semaglutide vs Tirzepatide — Which One Helps You Lose Weight Faster?

If you’re trying to choose between Semaglutide (Ozempic/Wegovy) and Tirzepatide(Mounjaro/Zepbound), here’s the truth:

Which Works Faster?

Tirzepatide.

Most patients see quicker results and more total weight loss.

• Semaglutide:Avg. 15% body weight loss
• Tirzepatide:Avg. 22–25% body weight loss

Why Tirzepatide Works Better?

Tirzepatide targets two hormones (GLP-1 + GIP) instead of one →

Stronger appetite control

Faster metabolism

More fat-burning pathways activated

Appetite & Cravings

• Semaglutide:Strong suppression
• Tirzepatide:Stronger + lasts longer

Most clients say tirzepatide “turns off cravings” completely.

How Fast Will You Lose Weight?

• Semaglutide:1–3 lbs/week
• Tirzepatide:2–5 lbs/week

Side Effects

Both cause mild nausea, but tirzepatide is often easier to tolerate because of its dual-hormone balance.

Who Should Choose What?

Choose Semaglutide if:

You want slow, steady weight loss

You have mild-moderate goals (10–25 lbs)

Choose Tirzepatide if:

You want faster results

You have 30–100+ lbs to lose

You struggle with cravings

Tirzepatide is the faster, stronger medication for most people.

Semaglutide is excellent — but if your goal is maximum fat loss, tirzepatide usually wins.